Abstract: We study some classes of nonlinear dispersive PDEs with potentials in both 1 and 3 dimensions, motivated by questions on the stability of solitons and topological solitons. Our approach is based on the so-called “distorted Fourier transform” adapted to Schrodinger operators, and the development of multilinear harmonic analysis in this setting. This approach allows us to treat low power nonlinearities and describe the global space-time behavior of solutions, also by capturing singularities in frequency space which may arise due to various coherent phenomena. Several application will be discussed along with related open problems.